Twenty-two Centennial Conference men's lacrosse players have been recognized as All-Americans by either the United States Intercollegiate Lacrosse Association (USILA) or USA Lacrosse Magazine, with four players receiving accolades from both organizations. 

Dickinson's Jack Deady was named to the USILA second team while Gettysburg's Will Hedley earned second team honors from USA Lacrosse Magazine to lead the way for the contingent of CC all-stars. Muhlenberg's Chase Kusko and Dickinson's Hayden Warren received third team honors from USA Lacrosse Magazine. The remaining honorees were honorable mention picks. 

Hedley, Kusko, Swarthmore's Clay Almgren and Washington College's Brian Blanche collected awards from both organizations.